A randomized control trial to evaluate the effect of local instillation of mitomycin-C at the porta after kasai portoenterostomy in patients of biliary atresia
Background: Kasai portoenterostomy (KPE) is the initial treatment for biliary atresia (BA).Even after initial jaundice clearance, a significant number of children presented with the reappearance of symptoms due to ongoing fibrosis involving porta and intrahepatic ducts.Mitomycin-C (MMC) is an antifibrotic agent, and the study hypothesized that loca